Utvalgte, gjennomførte Smartfish studier
Utvalgte, pågående Smartfish studier
Utvalgte, eksterne studier
Mental Helse

Navn/beskrivelse: Reduction in behavior problems with omega-3 supplementation in children aged 8-16 years: a randomized, double blind, placebo-controlled stratified, parallel-group trial.

Institusjon: Department of Criminology, Psychiatry and Psychology, University of Pennsylvania, Philadelphia. (Adrian Raine1, Jill Portnoy, Jianghong Liu, Tashneem Mahoomed, Joseph R. Hibbeln)

Målsetning: This study tests the hypothesis that omega-3 supplementation over 6 months will reduce behavior problems in children both at the end of treatment and at 6 months post treatment.

Konklusjon: Findings provide initial evidence that omega-3 supplementation can produce sustained reductions in externalizing and internalizing behavior problems. Results are the first to report improvements in caregiver behavior, and to establish this improvement as a part-mechanism for the efficacy of omega-3.

Biotilgjenglighet og toleranse

Navn/beskrivelse: Effects of a convenience drink fortified with n-3 fatty acids on the n-3 index

Institusjon: Department Preventive Cardiology, Medizinische Klinik-Innenstadt and Poliklinik Innenstadt, Ludwig-Maximilians-University, Ziemssenstrasse 1, D-80336 Munich, Germany. Anton Köhler, Daniel Bittner, Anja Löw and Clemens von Schacky*

Målsetning: The aim of the present study was to evaluate the effect of a convenience drink enriched with 500 mg EPA and DHA on the n-3 index, a biomarker of EPA and DHA status in an individual.

Konklusjon: Signifikant økning i omega-3indeks. Trygg, godt tolerert og velsmakende

Oksidativt stress og inflammasjon

Navn/beskrivelse: Effect of Smartfish and other commercial marine oil products on lipid peroxidation in U937 cells

Institusjon: University of Oslo Department of Nutrition Sognsvannsveien 9 0372 Oslo, Dr. Harald Carlsen Dr. Fred Haugen

Målsetning: To investigate the degree of lipid peroxidation in cell membranes of U937 cells following incubation of Smart-fish juice and gelatin capsule based marine oils rich in omega 3 fatty acids. The marine oils from capsules were supplemented with lycopene and lutein to see whether these antioxidants would influence the degree of lipid peroxidation compared with Smartfish-juice.

Konklusjon: In conclusion, the data strongly suggest that Smartfish-juice seems to offer a greater protection against lipid peroxidation than other suppliers of marine oil products

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Tidlig fase Alzheimers / mild kognitiv svikt

Navn/beskrivelse: Smartfish har et flerårig utviklingsprogram med professor Milan Fiala, UCLA. Vi presenterer her et delprosjekt som ble publisert på ICAD 2013: Personalized medicine approcach to prevention of Azheimers disease: Omega-3 fatty acids & vitamin D3 in vitro and in Smartfish drink invivo attenuate inflammation and improve amyloid-β phagocytosis in patients with Alzheimer disease.

Institusjon: UCLA, Milan Fiala

Målsetning: Omega3 docosahexaenonic acid(DHA) and vitamin D3 popular as nutritional supplements against dementia.DHA is a precursor of the lipid modulators resolvin D1 and D2 (RvD1) and neuroprotectins (NPD1). The hormonal form of vitamin D3 1,25dihydroxyvitamin D3 (1,25D3) has positive genomic and nongenomic effects in the innate immune system. Although epidemiological studies have shown the effectiveness of omega-3 and vitamin D3 supplementation against cognitive decline, their mechanisms and individual effectiveness in patients with Alzheimer disease (AD) are not understood. Current understanding of amyloid–β (Aβ1-42) signaling in PBMCs and the mechanisms of 1,25D3 and RvD1 are shown.

Hjerte og kar

Navn/beskrivelse: Omega 3 on CVD and T2D

Institusjon: Jagiellonian University, Poland, Gregorsj Gajos

Målsetning: The objective of the current study is to evaluate the effects of omega-3 polyunsaturated fatty (PUFA) acids administered on top of optimal therapy of atherosclerotic cardiovascular disease (CVD) and type 2 diabetes (T2D) on endothelial function, platelet aggregation and thrombotic, inflammatory and oxidative stress biomarkers.

Kreft

Navn/beskrivelse: OmegaChild

Institusjon: Karolinska Institutet, Per Kogner

Målsetning: Establish optimal dosing of omega-3 fatty acid supplements in children diagnosed and treated for cancer.

Kols

Navn/beskrivelse: Trial of Omega 3 rich nutritional Supplemets in COPD

Institusjon: University of Southampton, Tom Wilkinson

Målsetning: A pilot study of effects of high dose omega-3 in patients with COPD

Muskler og restitusjon

Navn/beskrivelse: The importance of fish oils for facilitating muscle recovery from damaging exercise in competitive soccer players

Institusjon: University of Stirling, Oliver Witard and Kevin Tipton

Målsetning: 1) To investigate the impact of fish oil supplementation on putative blood markers of muscle damage during recovery from a bout of muscle damaging exercise. 2) To investigate the impact of fish oil supplementation on blood markers of inflammation during recovery from a bout of muscle damaging exercise. 3) To investigate the impact of fish oil supplementation on perceived feelings of muscle soreness during recovery from a bout of muscle damaging exercise. 4) To investigate the impact of fish oil supplementation on vertical jump performance performed subsequent to a bout of muscle damaging exercise. 5) To investigate the impact of fish oil supplementation on 5, 10 and 15 m sprint performance during recovery from a bout of muscle damaging exercise. 6) To investigate the impact of fish oil supplementation on the performance of a soccer-specific agility test (T-test) during recovery from a bout of muscle damaging exercise. 7) To investigate the impact of fish oil supplementation on the performance of anaerobic capacity during recovery from a bout of muscle damaging exercise.